Retinitis pigmentosa is a clinical and genetic group of inherited retinal disorders characterized by alterations of photoreceptors and\nretinal pigment epithelium leading to a progressive concentric visual field restriction, which may bring about severe central vision\nimpairment. Haemodynamic studies in patients with retinitis pigmentosa have demonstrated ocular blood flow abnormalities\nboth in retina-choroidal and in retroocular vascular system. Moreover, several investigations have studied the augmentation of\nendothelin-1 plasma levels systemically in the body and locally in the eye. This might account for vasoconstriction and ischemia,\ntypical in vascular dysregulation syndrome, which can be considered an important factor of reduction of the ocular blood flow in\nsubjects affected by retinitis pigmentosa.
Loading....